THE POTENTIAL OF PROTEOME IN ONCOLOGICAL CELL THERAPY Giovanna Guimarães Lombardi

Abstract

Proteomic analysis has become increasingly studied, being characterized as the “post-genomic” era. This relevance is due to it being a potential biomarker, indicating a discovery, such as new bioactive molecules, for example, and/or clarifying metabolic processes through their products. Unlike an organism's genome, which remains relatively stable throughout life, the proteome is characterized as extremely variable and dynamic. Cellular therapy through proteomes also gains recognition, especially in oncological and neurological therapies as they have an individual character for each diagnosis. The analysis of these macromolecules makes it possible to know if and when a genetic product was expressed, its relative concentration and the modifications that may occur in these proteins after translation. The potential of oncological cell therapy is in relation to knowledge of the signaling dynamics of a cancer cell, which is one of the main factors that favor its pathological and metastatic processes. Therefore, the objective of this work is to elucidate the specificity of this analysis for advances in personalized medicine, directly reflecting on preventive medicine. The study will be carried out through a systematic review of the literature through the electronic databases SciELO (Scientific Electronic Library Online), PubMed and Clinical trials. The following search terms will be included: “Proteome” OR “Proteomics” IN “Cell Therapy” AND “Biomarkers” IN “Cancer” OR “Oncology” and their English counterparts. Articles that are not available in English and Portuguese will be excluded from the search, as well as articles that do not have their abstracts and/or full versions available in the search databases.