Inflammation and cardiovascular disease. Hermes Toros Xavier, Henrique Fortunato Dominguez Pita

Abstract

Atherosclerosis is an inflammatory disease characterized by an alteration in vascular biology. Elevated LDL-C levels, which generate endothelial dysfunction, oxidative stress and the release of different inflammatory mediators in vascular tissue, expanding the tissue repair process, at all stages of the progression of the atherosclerotic plaque that can lead to Cardiovascular Disease. In this short note we bring together works by authors who brought new information on the topic: 1) the premise that the cholesterol-inflammation binomial (LDL-C and hsCRP) can potentially configure a double objective of treatment; 2) testing the inflammatory hypothesis of atherothrombosis, evaluating the impact of the addition of canakinumab, a monoclonal antibody against IL-1beta, on the recurrence of CV events in secondary prevention patients and with optimized standard therapy; 3) heart attack patients benefit from the use of a low dose of colchicine, starting early, in the hospital.