THE IMPORTANCE OF MOLECULAR CHAPERONES IN NEURODEGENERATIVE DISEASES

Abstract

Molecular chaperones are essential in the monitoring of protein homeostasis and its possibility as a therapeutic target has been investigated for neurodegenerative diseases. There is experimental evidence that the expression of these proteins decreases the formation of protein aggregates that are particular of neurodegenerative diseases through refolding or targeting for degradation of misfolded proteins that form these aggregates. As intermediate aggregates are more toxic than compact ones, their inhibition may be an innovative feature for the advance of new drug therapies. Even so, most scientific evidence shows improvement in the neurodegeneration through induction of these molecules.