PROPOSAL FOR THE SYNTHESIS OF A NEW ESTROGEN-NITROSOUREA DERIVATIVE AS A CANDIDATE FOR ANTINEOPLASTIC DRUG

Abstract

The expression of the estrogen receptor and its notable position in the progression of most breast cancers suggested conjugation to improve antineoplastic therapy. Thus, platinum complexes linked to estrogen via Cu(I)-catalyzed azide-alkyne click chemistry and steroid-nitrosourea conjugates have shown promising results. However, no attempts to synthesize steroid-nitrosourea conjugates using click chemistry have been found. This study aims to propose the synthesis of a new estrogen-nitrosourea derivative, a candidate for antineoplastic drug development. The proposed synthesis is similar to that described in the literature for related molecules in functional groups.

Keywords: Nitrosourea Compounds; Estradiol; Click Chemistry; Triazoles.