RHIZOPHORA MANGLE BARK AND LEAVES EXTRACTS: ANTIOXIDANT AND IMMUNOMODULATORY ACTIVITY IN MACROPHAGES IN AN ANTI-INFLAMMATORY PROPHILAXY SCENARIO

Abstract

Mangroves are ecosystems rich in several phytochemical components of relevant biological activity. The "red mangrove" (Rhizophora mangle) contains several phytochemical compounds associated with various biological activities, which contributes to its use in folk medicine as an anti-inflammatory, antibacterial, antioxidant and antipyretic. In this study, the antioxidant, anti-inflammatory and cytotoxic activities of R. mangle leaf and bark extracts were evaluated, using cell viability (MTT), antioxidant potential by reaction with DPPH and quantification of the pro-inflammatory cytokine IL-1β. The results demonstrated a dose-dependent antioxidant activity, a decrease in cell viability, and little influence on the reduction of pro-inflammatory cytokine production, creating space for a new approach with regard to the biological activities of the extracts and their possible role in tumor cell lines