OFF-LABEL USE OF ANTIPSYCHOTICS IN THE TREATMENT OF BORDERLINE PERSONALITY DISORDER: A COMPARATIVE STUDY BETWEEN THE SCIENTIFIC LITERATURE AND PATIENT EXPERIENCE

Abstract

The term BPD (borderline personality disorder) was initially proposed by Adolph Stern in 1938 to describe patients who fell somewhere between psychotic and neurotic conditions. Although there are no formally approved medications for its treatment, off-label use of antipsychotics is common. This research aims to critically analyze this practice through an integrative review (PubMed, SciELO), as well as by analyzing clinical guidelines from agencies such as ANVISA and CFM. Olanzapine, quetiapine, and aripiprazole received the most positive feedback, but only olanzapine received more support than criticism. Polypharmacy is not supported by current evidence and should be avoided whenever possible. This reinforces the need for further studies to establish sound recommendations