IN SILICO ASSESSMENT OF THE ECOTOXICITY OF ANTINEOPLASTIC DRUGS USED IN PANCREATIC CANCER TREATMENT

Abstract

Due to growing concern about the presence of pharmaceuticals in the environment, there has been an increase in studies focused on monitoring and their potential environmental impacts. In this context, this study aimed to evaluate the ecotoxicity of 10 antineoplastic drugs used in the treatment of pancreatic cancer, using toxicity prediction models (acute and chronic) using the ECOSAR v1.11 software. The ecotoxicological potential of the substances was analyzed in aquatic organisms representing three trophic levels: algae, crustaceans, and fish. The results revealed that several drugs used in the treatment of pancreatic cancer have significant ecotoxicological potential in aquatic organisms