PREDICTION OF ENVIRONMENTAL TOXICITY OF ANTINEOPLASTIC CHEMOTHERAPEUTIC DRUGS USED IN THE TREATMENT OF LUNG CANCER

Abstract

Pharmaceutical pollution has been detected in the environment, and various studies demonstrate that many substances have the potential to affect aquatic life in their original form or as metabolites. Therefore, this study aims to evaluate the predicted ecotoxicity of 10 antineoplastic chemotherapy drugs used in the treatment of lung cancer using the ECOSAR v1.11 software and classify the results according to European Directive 93/67/EEC. The results demonstrated high toxic potential, particularly for alectinib, dacomitinib, entrectinib, and ceritinib. The data obtained may contribute to planning actions aimed at reducing the burden of pharmaceutical products on the aquatic environment