Environmental Impact Assessment of Drugs: Prediction of Drug Toxicity to Aquatic Organisms Renato Sakai Cid, Maisa da Cruz Figueira, Luciana Lopes Guimarães

Abstract

Drugs and personal care products that reach the environment from domestic waste or the waste generated in their production are of growing concern. At concentrations in the order of micrograms per liter (short-term ineffective concentrations in terms of biological response in humans), they can cause major impacts on the environment by chronic exposure, interfering with species physiology, metabolism and behavior. This work aims to conduct structure-ecotoxicity (ECOSAR) studies of 37 compounds (drugs and illicit drugs) and to estimate the occurrence of human metabolites of 8 compounds that were detected in surface waters previously collected in the area of ​​influence of the submarine outfall of Santos.