Does diclofenac dnterfere with the embriolarval development of sea drchins? Juliana Andrade de Sousa, Rafaela Amaral Gomes dos Santos, Fabio Hermes Pusceddu, Luciane Alves Maranho

Abstract

The physicochemical properties of drugs are not completely removed by conventional wastewater treatment, which can have adverse effects on marine organisms. Chronic toxicity tests were carried out with the drug diclofenac, o it is one of the most used worldwide anti-inflammatory drugs in the world, and it causes several known adverse effects on human health, but few known in marine organisms. This study aimed to verify in the laboratory the chronic toxicity of diclofenac to sea urchin embryos Echinometra lucunter, being exposed to concentrations of the drug: 1.56 mg / L; 3.12 mg / L; 6.25 mg / L; 12.5 mg / L, 25 mg / L; 50 mg / L and 100 mg / L. Diclofenac was toxic causing abnormal embriolarval development at concentrations above 25 mg / L. Proof of its toxicity is of utmost importance, in order to regulate standards that monitor and preserve the marine ecosystem, since this is a widely used drug.