Predictive Analysis of the Ecotoxicity of Drugs used in the Experimental Treatment Against COVID-19 Rafael Barreiros Kiyotani, Vinicius Roveri, Luciana Lopes Guimarães

Abstract

 Over the past 20 years, concerns have arisen about pharmaceuticals and personal care products in the environment from household waste and manufacturing.  Low concentrations of these compounds (ng.L-1 to µg.L-1) can cause environmental damage, especially in aquatic environments, affecting organisms.  The present study aimed to evaluate the ecotoxicity of 9 drugs used experimentally in COVID-19 using the ECOSAR v1.11 software. The results classified the drugs, highlighting Remdesivir, Lopinavir, and Ritonavir as extremely toxic.  The study highlights the importance of ecotoxicological research for all drugs and metabolites, encouraging sewage treatment actions to reduce impacts on aquatic ecosystems.